Blar i forfatter "Brun, Vegard Heimly"

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    • Hippocampal growth hormone modulates relational memory and the dendritic spine density in CA1 

      Haugland, Kamilla Gjerland; Olberg, Anniken; Lande, Andreas; Kjelstrup, Kirsten Brun; Brun, Vegard Heimly (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02)
      Growth hormone (GH) deficiency is associated with cognitive decline which occur both in normal aging and in endocrine disorders. Several brain areas express receptors for GH although their functional role is unclear. To determine how GH affects the capacity for learning and memory by specific actions in one of the key areas, the hippocampus, we injected recombinant adeno-associated viruses (rAAVs) ...

    • Making wise decisions for completion thyroidectomies 

      Brun, Vegard Heimly; Brauckhoff, Katrin (Journal article; Tidsskriftartikkel, 2022-11-25)
      <p>Unilateral differentiated thyroid cancer (DTC) <4 cm can be treated with thyroid lobectomy or total thyroidectomy (TT), depending on the presence of high-risk features. Information about some of these features, such as micrometastasis in lymph nodes or microscopic extrathyroidal extension (ETE), are usually incidental findings that only become available after histological assessment from the first ...

    • Patient-tailored levothyroxine dosage with pharmacokinetic/pharmacodynamic modeling: A novel approach after total thyroidectomy 

      Brun, Vegard Heimly; Eriksen, Amund H.; Selseth, Ruth; Johansson, Kenth; Vik, Renate; Davidsen, Benedicte; Kaut, Michal; Hellemo, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-07)
      Background: After seven decades of levothyroxine (LT4) replacement therapy, dosage adjustment still takes several months. We have developed a decision aid tool (DAT) that models LT4 pharmacometrics and enables patient-tailored dosage. The aim of this was to speed up dosage adjustments for patients after total thyroidectomy.<p> <p>Methods: The DAT computer program was developed with a group of 46 ...

    • Prediction of thyroid nodule histopathology by expert ultrasound evaluation 

      Håskjold, Olav Inge; Foshaug, Henrik Stenestø; Iversen, Therese Benedikte; Kjøren, Helga Charlotte; Brun, Vegard Heimly (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-17)
      <i>Objective</i> - The basis of thyroid nodule diagnostics is ultrasound-guided fine needle biopsy with cytological evaluation (FNC) if ultrasound appearance is not clearly benign. The aim of this study was to investigate the predictive potential of dedicated, expert high-resolution ultrasound, to see if histopathological entities of thyroid nodules can be diagnosed without invasive FNC biopsies.< ...

    • Severe hypercalcemia caused by parathyroid hormone in a rectal cancer metastasis: a case report 

      Brun, Vegard Heimly; Knutsen, Erik; Stenvold, Helge; Halvorsen, Hanne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-07)
      Background - Hypercalcemia of malignancy is relatively common in several cancers. However, in colorectal cancer, paraneoplastic phenomena that cause hypercalcemia is uncommon. In the few cases that are reported, secretion of parathyroid hormone-related peptide mediates the effect. We describe the first case of severe hypercalcemia mediated by intact parathyroid hormone secretion from a bone metastasis ...